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Epstein-Barr Virus–Associated Leiomyosarcoma of the Iris in a Child Infected With Human Immunodeficiency Virus
Arch Ophthalmol. 2003;121:1478-1481.
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Children with human immunodefiency virus (HIV) infection have a higher risk of developing a malignant neoplasm, the most common of which is non-Hodgkin lymphoma, followed by leiomyosarcoma.1-2 Most leiomyosarcomas in children with HIV infection have been found in various anatomical locations, including the gastrointestinal tract, liver, spleen, and lung.3-4 The association between leiomyosarcoma and Epstein-Barr virus (EBV) infection in HIV-infected patients is known.5
Reports from 19646 and 19727 described smooth muscle tumors in the iris. Foss et al,8 using immunohistochemical analysis, have reclassified previous reported cases as melanocytic lesions. As a result, stricter pathologic criteria for diagnosing intraocular neoplasms of smooth muscle were established in 1994.8 Since then, there has been only one well-documented example of iris leiomyoma reported.9 We report an HIV-infected girl with an iris neoplasm, histologically and immunohistochemically proven to be leiomyosarcoma.
Report of a Case
A 4-year-old Thai girl with vertically acquired HIV infection was born at our hospital in . . . [Full Text of this Article]
Comment
Wasee Tulvatana, MD;
Chitsanu Pancharoen, MD;
Jutarat Mekmullica, MD;
Usa Thisyakorn, MD;
Uraiwan Tinnungwattana, MD;
Kanista Keetacheeva, BEd;
Shanop Shuangshoti, MD
Bangkok, Thailand
Somruetai Shuangshoti, MD
Nonthaburi, Thailand
Corresponding author and reprints: Wasee Tulvatana, MD, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University Hospital, 1873 Rama IV Rd, Bangkok 10330, Thailand (e-mail: wasee.t@chula.ac.th).
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