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Corneal Juvenile Xanthogranuloma in a 4-Month-Old Child
Arch Ophthalmol. 2003;121:117-118.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Juvenile xanthogranuloma (JXG) is a benign histiocytic disease of uncertain pathogenesis that usually appears as a cutaneous lesion(s) in the head and neck region of young children. Diagnosis is based on histological examination that shows a nodular, dense infiltrate of polygonal or spindled mononuclear cells with moderate amounts of cytoplasm and scattered Touton giant cells. Juvenile xanthogranulomas are typically positive for CD68 and factor XIIIa immunostains and are negative for CD1a and S100 protein; this information is helpful in differentiating JXG from other histiocytic proliferations.1 We present the case of a 4-month-old child with corneal JXG.
Report of a Case
The mother of a 4-month-old infant boy noted an enlarging, raised mass in the medial corner of his right eye. A biopsy performed by a local ophthalmologist was interpreted as noncaseating granulomatous inflammation. Despite normal findings on systemic evaluation, sarcoidosis was diagnosed. He received topical steroid therapy and was referred to us.
Examination of . . . [Full Text of this Article] Comment
Corresponding author and reprints: Matthew W. Wilson, MD, Department of Ophthalmology, University of Tennessee Health Science Center, 956 Court Ave, D-228, Memphis, TN 38163 (e-mail: mwilson@mail.eye.utmem.edu).
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