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Arch Ophthalmol. 2002;120:1211-1212.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A 63-year-old woman developed discoloration of the silicone intraocular lens (IOL) implants in both eyes after receiving 300 mg of rifabutin by mouth, once daily, for 10 months. Examination revealed a rose color to both implants, though the patient reported minimal visual deficit. We then investigated the effect of rifabutin on 3 different common IOL materials and found that it only affected silicone. Though rifabutin is well known to cause discoloration of body fluids and soft contact lenses, this case illustrates this process occurring in IOL implants.

Rifabutin is indicated for prophylaxis against Mycobacterium avium complex (MAC), which is primarily seen as a coinfection with human immunodeficiency virus (HIV). Shown to cause discoloration in certain body fluids, including tears, saliva, and perspiration, rifabutin prescribing guidelines specifically caution that soft contact lenses may be permanently stained subsequent to its use.¹ However, to our knowledge, the occurrence in an IOL has not . . . [Full Text of this Article]

Report of a Case


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Corresponding author and reprints: Alan Emory Irwin, MD, Division of Ophthalmology, Fletcher Allen Health Care, UHC Fourth Floor, Burlington, VT 05405 (e-mail: airwin@vtmednet.org).

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