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Late Malignant Melanoma After Treatment of Rhabdomyosarcoma of the Orbit During Childhood
Arch Ophthalmol. 2002;120:1087-1090.
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A 27-year-old woman developed malignant orbitoconjunctival melanoma
in her left eye 21 years after treatment of a left orbital embryonal sarcoma
with systemic chemotherapy and radiation therapy to the orbit. The coexistence
of these 2 malignancies in the same orbit is very rare. It may be coincidental,
but a genetic predisposition or late adverse effects of childhood cancer treatments
cannot be excluded.
Second malignant tumors can occur in patients treated for retinoblastoma
during childhood,1 but other multiple ophthalmic
malignancies in the same patient are a very rare occurrence. We report the
case of a patient who had 2 distinct tumors involving her left orbit. A childhood
sarcoma was followed 21 years later by a malignant melanoma.
Report of a Case
In 1971, a 6-year-old girl developed a tumor in her left orbit. A specimen
from an incisional biopsy of the mass showed evidence of embryonal sarcoma
(Figure 1 A and B). The patient
. . . [Full Text of this Article]
Comment
Corresponding author and reprints: Livia Lumbroso, MD, Institut Curie,
26 Rue d'Ulm, 75005 Paris, France (e-mail: livia.lumbroso@curie.net).
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