Paradoxical Intraocular Pressure Elevation After Combined Therapy With Latanoprost and Bimatoprost
Arch Ophthalmol. 2002;120:847-849.
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Latanoprost is a prostaglandin F2aanalogue prodrug that is
used in the management of ocular hypertension and glaucoma. Latanoprost is
widely prescribed and has displayed ocular hypotensive efficacy greater than
that exhibited by timolol maleate in controlled comparative studies.1-4
The effect on intraocular pressure (IOP) seems to be caused by increased uveoscleral
outflow.5-6
Bimatoprost is a new ocular compound that appears to mimic the prostamides.
Prostamides are the most recently described members of the fatty-acid amide
family and are potent ocular hypotensive agents. Bimatoprost also has been
shown to have superior hypotensive efficacy compared with timolol.7-8 Bimatoprost seems to work by
enhancing pressure-independent aqueous outflow, presumably corresponding to
uveoscleral outflow and conventional outflow through the trabecular meshwork.
Bimatoprost has also been noted to increase aqueous production.9
We have recently noted 3 patients who have demonstrated marked paradoxical
IOP elevation after adding bimatoprost to the treatment regimen of an eye
already . . . [Full Text of this Article] Report of Cases
Case 1 Case 2 Case 3
Comment
Corresponding author: Leon W. Herndon, MD, Duke University Eye Center,
PO Box 3802, Durham, NC 27710 (e-mail: hernd012@mc.duke.edu).
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Br. J. Ophthalmol. 2005;89:547-549.
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