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Arch Ophthalmol. 2002;120:844-846.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

An important method of conservative therapy for retinoblastoma during the past 50 years has been external beam radiotherapy. In general, this modality offers favorable tumor control, but subsequent monitoring for local recurrence and application of salvage therapy have been emphasized. Several authors have observed that recurrence is usually detected within 1 year of therapy.^1-2 We report late-onset choroidal recurrence of retinoblastoma 25 years following therapy.

Report of a Case

A 25-year-old Latin American woman noticed sudden, painless visual loss in her only eye on awakening. Visual acuity was hand motions OD; the left eye had been enucleated. She gave a history of bilateral sporadic retinoblastoma diagnosed at age 12 months and managed initially with chemotherapy and cryotherapy to the right eye and enucleation of the left eye. One year later, 2 tumor recurrences were detected at the site of previous cryotherapy scars superiorly and inferonasally, measuring 1.5 x 1.5 x 1.0 mm and 12.0 . . . [Full Text of this Article]

Comment
Corresponding author and reprints: Carol L. Shields, MD, Ocular Oncology Service, Wills Eye Hospital, 900 Walnut St, Philadelphia, PA 19107.