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Arch Ophthalmol. 2002;120:835-844.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To identify histopathological changes induced by photodynamic therapy (PDT), 2 human eyes received PDT using verteporfin 1 week before enucleation for large malignant melanoma. Two light doses, 50 and 100 J/cm², were applied to unaffected chorioretinal areas and the optic disc using the standard procedure recommended for patients with age-related macular degeneration (ARMD).

Characteristic hypofluorescence following PDT was documented angiographically 1 week later. The enucleated globes were processed for standard light and electron microscopy.

The PDT-treated areas revealed uniform occlusion of the choriocapillary layer. Vascular endothelial cells were swollen, detached from the basement membrane, and showed rupture and fragmentation to complete degeneration. Capillary lumina were filled with cell debris, fibrin, and thrombocytes. Remaining intact endothelial cells seemed to generate novel vascular channels by recanalization of the obliterated lumen. The overlying retinal pigment epithelium (RPE) showed no significant alteration. Photoreceptors and optic nerve exposed to verteporfin and 100 J/cm² of . . . [Full Text of this Article]

Patients and Methods

Patients

Photodynamic Therapy

Clinical Documentation

Histopathological Evaluation

Results
Angiography

Light Microscopy

Electron Microscopy

Comment
Corresponding author: Ursula Schmidt-Erfurth, MD, Department of Ophthalmology, University Eye Hospital Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany (e-mail: uschmidterfurth@ophtha.mu-luebeck.de).

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