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Arch Ophthalmol. 2002;120(5):641-642.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

JAMA

Hormone Replacement Therapy and Dry Eye Syndrome

Debra A. Schaumberg, ScD, MPH; Julie E. Buring, ScD; David A. Sullivan, PhD; M. Reza Dana, MD, MPH

Context  Postmenopausal hormone replacement therapy (HRT) use is common in the United States. Some research suggests that estrogen may have detrimental effects on the tear film and could influence the development of dry eye syndrome, but few data are available on this relationship.

Objective  To determine the relationship of HRT and dry eye syndrome.

Design, Setting, and Participants  The Women's Health Study, a large cohort study in which 25 665 postmenopausal women provided information about use of HRT at baseline (1992), 12, and 36 months and dry eye syndrome at 48 months.

Main Outcome Measures  (1) Clinically diagnosed dry eye syndrome, as reported by participants; (2) severe symptoms (both ocular dryness and irritation either constantly or often); and (3) either clinically diagnosed dry eye syndrome . . . [Full Text of this Article]