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Endogenous Fungal Retinitis in a Patient With Acute Lymphocytic Leukemia Manifesting as Uveitis and Optic Nerve Lesion
Arch Ophthalmol. 2002;120:1754-1756.
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INTRODUCTION
Ocular infections continue to be an increasingly common complication in immunosuppressed patients. Endophthalmitis has been reported in immunosuppressed patients and patients who use intravenous drugs. Candida albicans is the most frequent cause of endogenous mycotic endophthalmitis.1 Other organisms include the Aspergillus and Fusarium species, Cryptococcus neoformans, Coccidioides immitis, Sporotrichum schenckii, Blastomyces dermatitidis, and Histoplasma capsulatum.1 Nonfungal organisms, such as the Pseudomonas and Salmonella species, may also cause endophthalmitis in immunosuppressed individuals.2
Ocular signs may be the first manifestation of leukemia or may be a manifestation of relapsed leukemia. Although the choroid is the most frequently affected ocular site in histopathologic studies,3 choroidal involvement may not be evident clinically. Leukemic retinopathy, infiltrates, microaneurysms, orbital and eyelid involvement,3-4 leukemic hypopyon,5 retinal detachment,6 and optic nerve head infiltration by leukemic cells7 have also been reported. Optic nerve involvement occurs mainly in children with acute lymphocytic leukemia.3 It is . . . [Full Text of this Article]
Report of a Case
Comment
Corresponding author and reprints: Timothy Murray, MD, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, PO Box 016880, Miami, FL 33101.
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