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Idiopathic Central Retinal Vein Occlusion in 2 Siblings With the 20210 GA Prothrombin Variant

Arch Ophthalmol. 2002;120:1752-1754.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Genetic variations in clotting factor genes may be very important in both venous and arterial thrombosis. Inherited thrombophilia has been associated with a deficiency of anticoagulant proteins such as protein C, protein S, antithrombin III (AT III), and factor V Leiden mutation.¹

Another procoagulant mutation, located in the 3'-untranslated region of the prothrombin (PT) gene 20210 GA PT mutation has recently been associated with an increased risk of venous thrombosis.² Franco et al³ thought the prevalence of the PT GA mutation was found to be 2- to 7-fold higher among patients with atherosclerotic disease than in healthy controls. Heterozygosity for the 20210 A allele was reported to be associated with increased PT (factor II of coagulation) and venous thromboembolism.^2-4 We report 2 cases of retinal vein occlusion (RVO) in 2 siblings who tested positive for the clotting factor II 20210 A variant.

Report of a Case

A 38-year-old white woman (patient 1) . . . [Full Text of this Article]

Comment

Reprints: Cristina Peris-Martínez, MD, Avda, Autopista del Saler 12, 3a planta, Puerta 7, University Hospital "La Fe," Department of Ophthalmology, 46013 Valencia, Spain (e-mail: cperis@ctv.es).

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