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Arch Ophthalmol. 2002;120:1742-1745.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

We report a case of nephropathic cystinosis, with corneal crystals, imaged and analyzed by in vivo confocal microscopy. The subject had a visual acuity of 6/6 OU. Slitlamp biomicroscopy revealed dense, hyperreflective cysteine crystals corresponding to a "Gahl score" of 2.75 to 3.00 in both eyes. In vivo confocal microscopy highlighted dense, polyhedral crystals throughout the posterior stroma and crisscrossing crystals of similar density throughout the anterior stroma. Quantitative assessment suggested that crystal density was lowest in the middle stroma. The longitudinal and transverse diameters of a total of 100 crystals for anterior and posterior stromal layers were measured and analyzed. The advantages of in vivo confocal microscopy for microstructural analysis of a living human cornea might provide useful information about the natural history of crystal deposition and growth throughout the stromal layers in subjects with cystinosis.

Infantile nephropathic cystinosis may affect vision due to corneal disease, retinopathy, or glaucoma.¹ . . . [Full Text of this Article]

Report of a Case

Results

Comment

Corresponding author: Charles McGhee, PhD, FRCOphth, Discipline of Ophthalmology, University of Auckland, Private Bag 92019, Auckland, New Zealand (e-mail: c.mcghee@auckland.ac.nz).

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