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High-grade Uveal B-Cell Lymphoma as the Initial Feature in Richter Syndrome
Arch Ophthalmol. 2002;120:1383-1385.
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We describe a patient with a 6-year history of chronic lymphocytic leukemia
who developed iris, ciliary body, and choroidal tumors associated with ocular
pain and uveitis that were unresponsive to topical anti-inflammatory steroids.
Because the eye was not salvageable with conservative treatment, enucleation
was performed. Findings from histopathologic examination of the enucleated
eye showed a high-grade B-cell lymphoma. This case represents an example of
Richter syndrome (high-grade lymphoma arising in patients with chronic lymphocytic
leukemia) clinically mimicking uveal melanoma.
Report of a Case
An 81-year-old woman complained of 4 weeks of blurred vision and 10
days of pain in the right eye. The eye had been treated with topical corticosteroids
and cycloplegics, prescribed by another ophthalmologist, for the 2 weeks preceding
our evaluation. Her vision was 6/200 OD and 20/25 OS. Intraocular pressure
was 18 mm Hg OU. There was no injection or chemosis of the conjunctiva. The
right eye had keratic precipitates and . . . [Full Text of this Article]
Comment
Corresponding author: Thaddeus P. Dryja, MD, Massachusetts Eye and
Ear Infirmary, 243 Charles St, Boston, MA 02114 (e-mail: dryja@helix.mgh.harvard.edu).
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