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Papillary Adenocarcinoma of the Iris Transmitted by Corneal Transplantation
Arch Ophthalmol. 2002;120:1379-1383.
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To our knowledge, there have been no reports of transmission of a systemic
malignancy from a donor to a recipient by corneal transplantation. Known cases
of transmission of disease by transplanted corneal tissue have involved infectious
agents1-14 and
1 case of intraocular tumor.15 Corneal tissue
from donors who have died of malignancy (with the exception of leukemia, lymphoma,
and retinoblastoma) has been considered safe for transplantation.15-19 In
contrast, there have been many reports of transmission of systemic malignancy
from donor to recipient by solid organ transplantation. The donor origin of
one case of tumor transmission by solid organ transplantation was proven conclusively
by DNA typing.20 We report the first known
instance, to our knowledge, of transmission of a systemic malignancy by corneal
transplantation, proven by DNA analyses.
Report of a Case
A 22-year-old man sought treatment in June 1992 because of a 2-week
history of slight irritation of his right eye and an area . . . [Full Text of this Article]
Comment
Corresponding author and reprints: Phillip J. Polkinghorne, FRCOphth,
Department of Ophthalmology, Auckland Hospital, Private Bag 92024, Auckland,
New Zealand (e-mail: philip@pjpolk.co.nz).
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