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Brain Necrosis After Enucleation, External Beam Cobalt Radiotherapy, and Systemic Chemotherapy for Retinoblastoma
Gilbert D. A. Padula, MD;
Beryl McCormick, MD;
David H. Abramson, MD
New York, NY
Corresponding author and reprints: David H. Abramson, MD, Department
of Ophthalmology, Weill Medical College of Cornell University, New York Presbyterian
Hospital, 525 E 68th St, New York, NY 10021 (e-mail: DHAMD@aol.com).
Arch Ophthalmol. 2002;120:98-99.
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A 3-YEAR-OLD girl was referred for treatment of an orbital mass. During
the autumn of 1998, she had an enucleation for unilateral retinoblastoma.
When her tumor recurred in the orbit with extension to her cheek and right
nose, she was treated with external beam radiotherapy in 10 fractions to a
dose of 3000 rad (30 gray [Gy]) prescribed to mid plane. She received her
treatment throughout a course of 2 weeks. She was treated with tangential
fields using a right anterior oblique portal and a left posterior oblique
portal. The field separation was 12 cm.
The response to radiotherapy lasted only a few months, so she was given
systemic chemotherapy consisting of cyclophosphamide, doxorubicin hydrochloride,
cisplatin, and etoposide in addition to intrathecal methotrexate, resulting
in shrinkage of the tumor. One year later, the tumor recurred again in the
. . . [Full Text of this Article] COMMENT
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