Intraocular Hemorrhages Due to Warfarin Fluconazole Drug Interaction in a Patient With Presumed Candida Endophthalmitis
Arch Ophthalmol. 2002;120:94-95.
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Fluconazole is a triazole antifungal effective against Candida endophthalmitis. It potentiates the anticoagulant effect of
warfarin sodium.1
Report of a Case
A 44-year-old man experienced worsening vision and floaters in both
eyes for 1 month. His medical history included alcoholism and pancreatitis.
He had been admitted to another hospital for parenteral hyperalimentation
via a central line, complicated by a deep venous thrombosis of his internal
jugular vein requiring anticoagulation with warfarin. His visual acuity without
correction was 20/400 OD and counting fingers at 3 ft OS. Slitlamp examination
revealed mild anterior chamber cells and anterior vitritis in both eyes. Funduscopic
examination revealed vitreous haze and multiple fluffy cotton-ball chorioretinal
opacities predominantly in the left eye (Figure 1). A diagnosis of bilateral Candida
endophthalmitis was made. The patient received an intravitreous injection
of 5 µg of amphotericin B in the left eye after vitreous biopsy, and
was administered 400 mg of oral fluconazole . . . [Full Text of this Article]
Comment
Corresponding author: V. Vinod Mootha, MD, University of New Mexico
Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87131-5341 (e-mail: vmootha@salud.unm.edu).
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