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Arch Ophthalmol. 2002;120:82-85.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The differential diagnosis of malignant melanoma of the uveal tract continues to challenge clinicians. In recent decades, we have come to expect a 95% or better accuracy in the clinical diagnosis of malignant melanoma, and in some centers such as the Wills Eye Institute, Baltimore, Md,¹ and the Mayo Clinic, Rochester, Minn,² 96.3% and 97.7% accuracies, respectively, have been reported. In 1990, a North American prospective randomized multicenter study group, the Collaborative Ocular Melanoma Study (COMS) Group, reported a 99.5% accuracy in the diagnosis of choroidal melanoma.³ By 1998, the COMS had enrolled more than 2300 eyes into the study, and among the 1532 eyes randomized and enucleated, 1527 were found to have a choroidal melanoma, resulting in a diagnostic accuracy of 99.67%.^4-6 The 5 misdiagnosed cases included 4 adenocarcinomas that metastasized to the choroid and 1 choroidal hemangioma. The low misdiagnosis rate in the COMS is a reflection of . . . [Full Text of this Article]

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Corresponding author and reprints: Dennis M. Robertson, MD, Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (e-mail: robertson.dennis@mayo.edu)

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