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Arch Ophthalmol. 2001;119:1210-1211.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Rarely, drugs, mostly sulfa-related compounds, have produced uveal effusions, forward rotation of the iris-lens diaphragm, transient myopia, and secondary angle closure.¹ We have recently encountered 2 cases in which uveal effusions have occurred after administration of topiramate (Topamax; Ortho-McNeil Pharmaceutical, Raritan, NJ), a new anticonvulsant medication.

Report of Cases

Case 1

A 34-year-old white woman was seen in our emergency department with severe headaches and progressively blurry vision in both eyes. Her medical history was notable for depression. Her ocular history was unremarkable, she had never worn glasses, and she denied ocular disease within the family. Her medications included clonazepam, buspirone hydrochloride, citalopram hydrobromide, orlistat, fluvoxamine maleate (a selective serotonin reuptake inhibitor [SSRI], which she started 2 days prior to initial examination), and topiramate (which she started 2 weeks prior to initial examination).

On examination her visual acuity was 20/250 OU. Slitlamp examination revealed trace conjunctival injection and chemosis, relatively clear corneas, and shallow anterior . . . [Full Text of this Article]

Case 2

Comment
Corresponding author: Cynthia L. Grosskreutz, MD, PhD, Department of Ophthalmology, Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114-3096.

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