Risk Factors for Glaucoma Progression
Where Does Intraocular Pressure Fit In?
Arch Ophthalmol. 2001;119:897-898.
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IN THIS ISSUE, Tezel et al1 present an analysis of risk factors for progression of glaucomatous optic disc damage in a cohort of patients undergoing treatment for either primary open-angle glaucoma or normal-tension glaucoma. As in some previous studies that were also well done but retrospective,2-3 they detected little if any role played by intraocular pressure (IOP).
Ophthalmologists could be easily misled by such studies to think that IOP matters little. Fortunately, additional studies that were better designed to test the role of IOP have shown conclusively that adequate IOP control can markedly reduce glaucomatous progression in normal-tension glaucoma4 and virtually halt it in primary open-angle glaucoma.5-6
How can there be such differing results of studies that purported to look at the role of IOP in glaucoma progression? Perhaps the best way one can illustrate the critical difference in study design that resulted in opposite conclusions is to consider the . . . [Full Text of this Article]
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