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Latanoprost and Periocular Skin Color Changes
Arch Ophthalmol. 2001;119:614-615.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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A 17 phenyl–substituted prostaglandin analog, 0.0005% latanoprost
decreases intraocular pressure by increasing uveoscleral outflow. Since its
introduction in 1996, several adverse effects have been reported, prominent
among which has been increased pigmentation of the iris and eyelashes. Although
darkening of the periocular skin is listed as an adverse effect in the product
insert, it has never been reported in the literature to our knowledge. We
describe 1 patient who had increased pigmentation of the periocular skin with
the use of latanoprost eye drops and decreased pigmentation within 2 months
of discontinuation of treatment with the eye drops.
Report of a Case
A 75-year-old woman with a 2-year history of open-angle glaucoma began
using 0.005% latanoprost eye drops in June 1998. In September 1999 she reported
that the skin around her eyes was much darker than the rest of her face (Figure 1). She stated that this darkening
had occurred gradually during the . . . [Full Text of this Article]
Comment
Corresponding author and reprints: Martin Wand, MD, Consulting Ophthalmologists,
PC, 85 Seymour St, #522, Hartford, CT 06106 (e-mail: nodhilwand@aol.com).
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