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Use With Caution

Arch Ophthalmol. 2001;119:576-578.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE REPORT by Klein et al¹ in this month's ARCHIVES, presenting further analyses of data from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR), raises interesting issues about the Early Treatment Diabetic Retinopathy Study² (ETDRS) retinopathy severity scale and its use in epidemiologic studies and clinical trials. After adding 2 steps in the mild nonproliferative range of the ETDRS retinopathy scale, the authors assessed whether a 1 or more or 2 or more step progression along the ETDRS retinopathy severity scale during a 4-year period is predictive of subsequent progression to proliferative retinopathy or clinically significant macular edema during the next 6 years. The results of the analyses of this well-designed and well-conducted population-based study, the WESDR, are displayed in Figure 3 of their article.¹ The data show that patients who had experienced a 1-step progression of retinopathy during the first 4 years of follow-up were 5.8 times more likely . . . [Full Text of this Article]

OUTCOME MEASUREMENT FOR CLINICAL TRIALS OF DIABETIC RETINOPATHY


DATA FROM THE DIABETES CONTROL AND COMPLICATIONS TRIAL

RELATED ARTICLE

How Many Steps of Progression of Diabetic Retinopathy Are Meaningful?: The Wisconsin Epidemiologic Study of Diabetic Retinopathy
Ronald Klein, Barbara E. K. Klein, and Scot E. Moss
Arch Ophthalmol. 2001;119(4):547-553.
ABSTRACT | FULL TEXT