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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Rapid removal of submacular hemorrhage caused by various diseases is essential to restore visual function. Today the use of intravitreally injected tissue plasminogen activator (tPA) and gas is an effective treatment to displace submacular hemorrhage. The study of Hrach and colleagues,¹ which evaluates toxic effects of intravitreally injected commercial tPA solution in the cat retina, is a substantial step toward confirming the safety of this procedure.

Toxic effects to the retina have been reported after intravitreal injection of tPA (100 µg/0.1 mL) in humans, causing retinal pigment epithelium hyperpigmentation, reduction of scotopic B wave amplitude, and exudative retinal detachment. It has also been confirmed morphologically in animal experiments.^1-3 However, based on the presented data of Hrach and colleagues, we do not agree that injections of commercial tPA "in concentrations greater than 25 µg/0.1 mL are potentially unsafe in human eyes." At least 4 arguments should be mentioned when discussing an . . . [Full Text of this Article]