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0.01% Becaplermin Gel for the Treatment of a Chronic Orbital Ulcer After Exenteration
Arch Ophthalmol. 2001;119:1858-1859.
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INTRODUCTION
Chronic orbital epithelial defect is a rare complication that occurs after exenteration. Skin grafts, rotation flaps, or free flaps are the traditional surgical means to correct such abnormalities. We describe a case of a chronic orbital epithelial defect after exenteration refractory to conventional treatment that resolved after being treated with 0.01% topical becaplermin gel (recombinant human platelet–derived growth factor BB [rh-PDGF-BB] or Regranex [Ortho-McNeil Pharmaceuticals Inc, Raritan, NJ]).
Report of a Case
A 57-year-old African American patient with a history of hypertension, seizures, and diabetes underwent a subtotal exenteration with placement of a full-thickness skin graft for primary orbital melanoma. The orbital defect healed slowly for several weeks. A year later the patient underwent placement of craniofacial orbital implants for retention of an orbital prosthesis. Following this procedure, she developed an ulcer at the apex of the socket that measured 15 x 4 mm with elevated edges and what appeared to be granulation tissue . . . [Full Text of this Article]
Comment
Corresponding author: James W. Karesh, MD, Department of Ophthalmology, Krieger Eye Institute, Sinai Hospital of Baltimore, 2411 W Belvedere Ave, Baltimore, MD 21215 (e-mail: jkaresh@lifebridgehealth.org).
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