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Arch Ophthalmol. 2001;119:1721-1723.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Topiramate (Topomax; Ortho-McNeil Pharmaceutical Inc, Raritan, NJ), an oral sulfamate, is used for the treatment of partial-onset seizures. We report the case of a patient with topiramate-induced acute bilateral myopia and angle-closure glaucoma with an echographic description of the pathogenic mechanism.

Report of a Case

A 43-year-old woman had blurred distance vision in both eyes, accompanied by a mild frontal headache. Her symptoms began 1 day after starting topiramate, progressed for 24 hours, and remained stable for the last 4 days before visiting the ophthalmologist. Prior to the onset of symptoms, she stated that she had excellent uncorrected distance vision and only used corrective lenses to read. She stopped her medication after 3 doses, at the onset of symptoms. Initial examination determined a visual acuity of 20/20 OU with a 5-diopter (D) myopic correction, narrow angles, and an intraocular pressure (IOP) of 29 mm Hg OD, and 30 mm Hg OS. Her medical history . . . [Full Text of this Article]

Comment

Corresponding author: Richard K. Parrish, MD, Bascom Palmer Eye Institute, University of Miami Medical School, 900 NW 17th St, Miami, FL 33313 (e-mail: rparrish@med.miami).

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