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The Possible Therapeutic Use of Limbal Stem Cell Transplantation

Arch Ophthalmol. 2001;119:120-122.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

PATHOPHYSIOLOGY OF CORNEAL DYSTROPHIES OF EPITHELIAL GENESIS

Classification of the primary corneal dystrophies has until now been based on biomicroscopic and pathologic features. Depending on the location of dystrophic deposits, the main anatomic groupings have been epithelial and subepithelial dystrophies, dystrophies primarily affecting the Bowman layer, stromal dystrophies, and endothelial dystrophies.

Recent advances in our understanding of the molecular genetics and pathophysiology of certain corneal dystrophies proffer a paradigm shift regarding the classification of these disorders. The greatest strides have occurred in the study of stromal corneal dystrophies. In 1994, Stone et al¹ mapped the genetic defect in 2 families with granular dystrophy, 2 families with lattice dystrophy, and 4 families with Avellino dystrophy to chromosome 5q. Subsequently, Munier et al² refined the location to chromosome 5q.31 for families with granular, lattice, Avellino, and Reis-Bucklers dystrophy, and isolated the candidate gene BIGH3 (the transforming growth factor –induced gene). Since then, mutations in this gene have been shown . . . [Full Text of this Article]

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Epithelial Origin of "Stromal" Corneal Dystrophies
Witschel et al.
Arch Ophthalmol 2002;120:101-101.
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