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Corneal Melting Associated With Use of Topical Nonsteroidal Anti-inflammatory Drugs After Ocular Surgery
Arch Ophthalmol. 2000;118:1129-1132.
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are used widely for systemic control of acute or chronic pain and inflammation. Topical NSAIDs have been used to effectively alleviate ocular inflammation after cataract removal and argon laser trabeculoplasty and to treat cystoid macular edema. They have also been used for pain control after radial keratotomy and excimer laser photorefractive keratectomy. Additional indications include allergic conjunctivitis and the prevention of miosis during cataract surgery. Despite the increased topical use of this class of drug after ocular surgery, corneal complications due to NSAID use have been uncommon. Reported complications include superficial punctate keratitis,1 subepithelial infiltrates,2 stromal infiltrates,3 immune rings,3 and persistent epithelial defects.4 In August 1999, severe complications associated with topical NSAID use, including corneal melting, were reported by members of the American Society of Cataract and Refractive Surgery (ASCRS) responding to a survey and distributed in letters from ASCRS to members and nonmembers. We report . . . [Full Text of this Article]Report of Cases
Case 1 Case 2 Case 3 Case 4 Case 5
Comment
Julianne C. Lin, MD;
Christopher J. Rapuano, MD;
Peter R. Laibson, MD;
Ralph C. Eagle, Jr, MD;
Elisabeth J. Cohen, MD
Philadelphia, Pa
Corresponding author: Elisabeth Cohen, MD, Cornea Service, Wills Eye Hospital, 900 Walnut St, Philadelphia, PA 19107 (e-mail: ejcohen@hslc.org).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Additional Factors Linking Corneal Melting to Topical Nonsteroidal Anti-inflammatory Drugs
Flach and Cohen
Arch Ophthalmol 2001;119:1085-1085.
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