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Combined Choroidal and Retinal Ischemia During Interferon Therapy: Indocyanine Green Angiographic and Microperimetric Findings
Arch Ophthalmol. 2000;118:580-582.
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This article presents findings from indocyanine green angiography (ICGA) and microperimetry in a patient with interferon (IFN)-associated combined choroidal and retinal perfusion deficits.
Report of a Case
A 40-year-old man was seen for central scotomas and blurred vision during treatment with IFN alfa-2b for metastatic renal cell carcinoma. Findings from retinal examination included cotton-wool spot formation and small hemorrhages. Findings from fluorescein and ICGA demonstrated areas of retinal as well as choroidal nonperfusion. Results of scanning laser ophthalmoscope microperimetry revealed central scotomas corresponding to choroidal perfusion defects. Cotton-wool spots and retinal hemorrhages disappeared during therapy over a 6-month period, but visual impairment and choroidal ischemia persisted. In addition to retinopathy, IFN therapy may also induce persistent choroidal perfusion changes associated with scotomization.
Our patient was seen for blurred vision in both eyes and reading difficulty for several months. Findings from the patient's medical history revealed renal cell carcinoma, for which he had undergone nephrectomy . . . [Full Text of this Article]
Comment
Hans Hoerauf, MD;
Ursula Schmidt-Erfurth, MD;
Mary Asiyo-Vogel, MD;
Horst Laqua, MD
Lübeck, Germany
Reprints: Hans Hoerauf, MD, Department of Ophthalmology, Medical University Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
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