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Persistent Hyperplastic Primary Vitreous Associated With Septo-optic-pituitary Dysplasia and Schizencephaly
Arch Ophthalmol. 2000;118:578-580.
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Persistent hyperplastic primary vitreous (PHPV), a form of persistent fetal vasculature, occurs infrequently with systemic conditions.1 We report the novel association of unilateral PHPV with septo-optic-pituitary dysplasia (SOPD) and ipsilateral schizencephaly.
Report of a Case
A full-term female neonate was born to a 17-year-old primigravid woman by cesarean delivery. On the third day of life, hypoglycemia and hypotonia raised the suspicion of sepsis, for which intravenous antibiotic therapy was administered. Microbiologic cultures were negative for organisms. The patient's condition stabilized and the neonate was discharged from the hospital.
On the ninth day of life, the patient was found ashen and unresponsive; she had suffered a grand mal seizure. On admission to a neonatal intensive care center, the patient was lethargic, hypotonic, hypoglycemic (1.270 mmol/L [23 mg/dL]), and hyperbilirubinemic (239.4 µmol/L [14.0 mg/dL]). Magnetic resonance imaging scans revealed an absent septum pellucidum, posterior ectopic pituitary gland, absent infundibulum, right closed lip schizencephaly, cortical dysplasia, and . . . [Full Text of this Article]
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Andreas Katsuya Lauer, MD;
Martin J. Balish, MD;
Earl A. Palmer, MD
Portland, Ore
Corresponding author: Andreas Katsuya Lauer, MD, Casey Eye Institute, Oregon Health Sciences Center, 3375 SW Terwilliger Blvd, Portland, OR 97201-4197.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Additional Considerations in Cases Involving Persistent Hyperplastic Primary Vitreous
Tripathi and Lauer
Arch Ophthalmol 2001;119:457-458.
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