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Arch Ophthalmol. 2000;118:577-578.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Retinoblastoma is the most common intraocular tumor in children.¹ Historically, the treatment of retinoblastoma was enucleation.¹ However, improvements in diagnosis and treatment of retinoblastoma have led not only to a survival rate well over 90%,¹ but also to an increasing ability to offer globe conservation as a secondary goal of therapy. Globe-conserving therapies include cryotherapy, laser photoablation, hyperthermia, and plaque radiotherapy for smaller tumors, and external beam radiation and systemic chemotherapy for larger tumors not amenable to local control.²

Recently, multiple-agent chemotherapy with etoposide phosphate, carboplatin, and vincristine sulfate combined with transpupillary hyperthermia has been demonstrated to achieve excellent local control of retinoblastoma.³ Further, systemic chemotherapy spares the patient the risk of craniofacial abnormalities and may eliminate or decrease the risk of secondary tumors that have been associated with external beam radiation.⁴ However, systemic chemotherapy employed for retinoblastoma has been associated with adverse events such as myelosuppression and subsequent infections . . . [Full Text of this Article]

Report of Cases


Comment
Matthew S. Benz, MD; Ingrid U. Scott, MD, MPH; Timothy G. Murray, MD; Deborah Kramer, MD; Stuart Toledano, MD
Miami, Fla

Corresponding author: Timothy G. Murray, MD, Bascom Palmer Eye Institute, 900 NW 17th St, Miami, FL 33136 (e-mail: tmurray@bpei.med.miami.edu).

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