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Arch Ophthalmol. 2000;118:426-427.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Fomivirsen sodium is a new oligonucleotide drug that acts as an antisense compound to inhibit viral protein translation. It is given as an intravitreal injection weekly for 3 weeks and then every 3 weeks for maintenance.¹ We report on retinal toxic effects associated with fomivirsen.

Report of a Case

A 41-year-old man with human immunodeficiency virus infection was seen with zone 2 cytomegalovirus (CMV) retinitis in his right eye on July 15, 1998. He had been enrolled in a phase III drug trial for fomivirsen sodium at a dose of 330 µg for treatment in his left eye. He was receiving 3000 mg a day of oral ganciclovir sodium to treat systemic CMV viremia (not part of study protocol). He was enrolled in the study, per protocol, at a dose of 165 µg for treatment in his right eye. The first injection was given on July 22, 1998, and was repeated on July 29 . . . [Full Text of this Article]

Comment
Haris I. Amin, MD
Rockford, Ill

Everett Ai, MD; H. Richard McDonald, MD; Robert N. Johnson, MD
San Francisco, Calif

Corresponding author: Haris I. Amin, MD, Northern Illinois Retina, 4855 E State St, Rockford, IL 61108 (e-mail: retinaguy@earthlink.net).

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