In the same manner in which epithelial defects of the cornea are recognized by the green coloration which arises when a solution of fluorescin is instilled into the conjunctival sac, it is possible when the epithelia are intact to demonstrate clinically endothelial defects in the depths of the cornea by the color which fluorescin produced. In addition to losses of endothelium it is possible to recognize changes which render the endothelium permeable. This may be proved experimentally.
By the aid of this method it can be proved that the so-called central parenchymatosa, which spreads inward from the periphery, is not occasioned by a primary endothelial affection, as far as may by maintained upon the basis of cases hitherto investigated.
Endothelial disease may further be demonstrated in buphthalmus.
Reference: von Hippel E. On the clinical diagnosis of endothelial alterations of the cornea and their significance in the interpretation of various affections . . . [Full Text of this Article]
