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Chlorpromazine-Induced Refractile Corneal Deposits and Cataract
Alfred T. S. Leung, FRCS, FRCOphth;
Arthur C. K. Cheng, MBBS;
Wai-Man Chan, FRCS;
Dennis S. C. Lam, FRCS, FRCOphth
Hong Kong, China
Arch Ophthalmol. 1999;117:1662-1663.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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A 50-YEAR-OLD Chinese woman who had had chronic schizophrenia was seen with a 1-year history of gradual deterioration of vision in both eyes associated with photophobia and glare sensitivity. Her schizophrenia has been stable for 26 years with a therapeutic regimen of chlorpromazine hydrochloride, 300 mg/d; trifluoperazine hydrochloride, 10 mg/d; and trihexyphenidyl hydrochloride, 4 mg/d. Findings from other medical and ocular histories were unremarkable. On ophthalmic examination, visual acuity was 20/35 OD and 20/50 OS. Slitlamp examination revealed fine, discrete, and brown refractile deposits on the corneal endothelium of both eyes (Figure 1). The corneal epithelium and stroma, however, were free from any deposits and the anterior chamber was clear. Intraocular pressure in both eyes was also normal. Additionally, characteristic bilateral stellate cataracts (Figure 2) with . . . [Full Text of this Article]COMMENT
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