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Sterile Mucopurulent Conjunctivitis Associated With the Use of Dorzolamide Eyedrops
Arch Ophthalmol. 1999;117:1429-1431.
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Dorzolamide hydrochloride, a nonbacteriostatic sulfonamide derivative, is the first topical carbonic anhydrase inhibitor clinically available. It reduces intraocular pressure by inhibiting aqueous humor production in the ocular ciliary processes.1
The most common adverse effects associated with dorzolamide use are bitter taste and local ocular complaints such as burning, blurred vision, itching, tearing, foreign body sensation, stinging, eyelid discomfort, and nonspecific conjunctival hyperemia.1-2 As dorzolamide represents a completely new class of topical ocular drugs, its spectrum of side effects is not yet as well defined as for older drugs. With the increased use of dorzolamide, it is important to be aware of possible unreported side effects that will invariably occur. We report the unusual finding of a severe sterile purulent conjunctivitis in 7 patients using dorzolamide drops that resolved immediately after discontinuation of treatment. We believe that this condition is most probably attributed to the use of this drug.
Report of Cases.
Case 1.
A 73-year-old . . . [Full Text of this Article] Case 2. Case 3. Other Cases.
Comment.
Corresponding author: Carl P. Herbort, MD, PD, Department of Ophthalmology, University of Lausanne, 15 Ave de France, CH-1004 Lausanne, Switzerland.
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