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Arch Ophthalmol. 1999;117:40.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Half an hour after a toxic dose of quinine is given to a dog, the retinal vessels become greatly constricted and vision is completely lost. After two or three days, a fair degree of vision returns, as a rule, and remains unless another dose is given.

In this investigation a number of dogs were killed at periods ranging from two hours to seven weeks after the first injection of quinine, and the eyes, optic nerves, brains and cords were examined by the Nissl methylen-blue method for cell changes and the Marchi osmic-acid method for nerve-fibre changes. Two hours after injection no changes were found. Retinas examined on the third day after several toxic doses had been given, revealed degenerative changes in a few ganglion cells (vacuolation, paleness and absence of chromophilic granules, breaking down of the cell body), and changes in the nerve fibres (a deposition in the nerve-fibre layer . . . [Full Text of this Article]