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Arch Ophthalmol. 1998;116:956-957.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1993, Johns and colleagues¹ described 2 monozygous twin brothers who had remained discordant for the development of Leber's hereditary optic neuropathy (LHON) for 6.5 years. Both brothers were found to harbor the identical homoplasmic 4216, 13708, and 11778 mitochondrial DNA mutations. Twin A developed bilateral optic neuropathy at the age of 34 years and had a visual acuity of 1/200 OU. At the time of the report, twin B was 41 years old and still had a visual acuity of 20/15 OU with no signs or symptoms of LHON. In this current report, updated information on twin B is provided and indicates that twin B has subsequently developed bilateral LHON.

Report of a Case

Twin B, now 45 years old, had remained healthy and visually asymptomatic until he noted painless, blurred vision while driving on the morning of September 23, 1997. The visual loss first occurred in the left eye and then in . . . [Full Text of this Article]

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Corresponding author: Byron L. Lam, MD, 900 NW 17th St , Miami, FL 33136.

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