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Long-term Persistence of Antirecoverin Antibodies in Endometrial Cancer-Associated Retinopathy
Arch Ophthalmol. 1998;116:251-253.
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Autoantibodies to recoverin are found in the serum of patients with cancer-associated retinopathy syndrome (CAR), in which retinal degeneration occurs in the presence of systemic tumor growth without metastasis to the eye. The presence of antirecoverin antibodies has, so far, been associated with small cell carcinoma of the lung. We describe a patient with an endometrial carcinoma who possesses T cells and antibodies that react with recoverin. The demonstration of autoantibodies in a patient's serum is important to the diagnosis of CAR and cancer and monitoring treatment of diseases. Although several studies have reported the presence of antibodies specific to CAR antigens even before the diagnosis of cancer, to date, no long-term follow-up studies have examined the prevalence of antirecoverin antibodies in those patients' recoverin.
Report of a Case
A 61-year-old white woman had endometrial cancer in 1991 and had had a hysterectomy for undifferentiated carcinoma with neuroendocrine features in September 1991. In July . . . [Full Text of this Article]
Comment
Grazyna Adamus, PhD;
Drake Amundson
Portland, Ore
Cynthia MacKay, MD;
Peter Gouras, MD
New York, NY
Corresponding author: Grazyna Adamus, PhD, R. S. Dow Neurological Sciences Institute, 1220 NW 20th Ave, Portland, OR 97209 (e-mail: Adamusg@nsi-lhs.org).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Antirecoverin Antibodies and Autoimmune Retinopathy
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Arch Ophthalmol 2000;118:1577-1578.
FULL TEXT
Cancer-Associated Retinopathy
Goldstein et al.
Arch Ophthalmol 1999;117:1641-1645.
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