New England Journal of Medicine
LACK OF EFFICACY OF LIGHT REDUCTION IN PREVENTING RETINOPATHY OF PREMATURITY
JAMES D. REYNOLDS, M.D., ROBERT J. HARDY, PH.D., KATHLEEN A. KENNEDY, M.D., RAND SPENCER, M.D., W.A.J. VAN HEUVEN, M.D., and ALISTAIR R. FIELDER, F.R.C.OPHTH., FOR THE LIGHT REDUCTION IN RETINOPATHY OF PREMATURITY (LIGHT-ROP) COOPERATIVE GROUP
Background Hospital-nursery lighting has been suggested as a factor causing retinopathy of prematurity. Despite ongoing debate, a causal relation has not been established.
Methods We conducted a prospective, randomized, multicenter study of the effects of light reduction on 409 premature infants with birth weights of less than 1251 g and gestational ages of less than 31 weeks. Two hundred five infants were exposed to reduced light, and 204 to typical nursery lighting. The amount of light reaching the infants' eyes was reduced within 24 hours after birth by placing goggles on the infants that reduced visible-light exposure by 97 . . . [Full Text of this Article]