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Michael E. Hettinger, MD, MS; Deborah Pavan-Langston, MD; No-Hee Park, DDS, PhD; Daniel M. Albert, MD; Erik De Clercq, MD; Tai-Shun Lin, PhD

Arch Ophthalmol. 1981;99(9):1618-1621.

Abstract
• The therapeutic efficacy of three new antiviral agents—5-iodo-3',5'-diacetyl-2-deoxyuridine (diacetylidoxuridine, 1% Ac₂IDU), E-5-(2-bromovinyl)-2'-deoxyuridine (0.25% BVDU), and 3% thymine arabinoside—is compared with available antivirals in an experimental model of herpes simplex virus type 1 (HSV-1) keratitis in New Zealand white rabbits. Compared with placebo, Ac₂IDU significantly reduced ulcerative keratitis on days 4 through 8 after inoculation with virus and iritis on day 8 after inoculation. Compared with placebo, thymine arabinoside reduced ulcerative keratitis but not significantly. Thymine arabinoside caused significant iritis in all eyes. The epithelial disease in BVDU-treated eyes was significantly less than that in placebo-treated eyes on days 5 through 8 after inoculation. The results indicate that 1% Ac₂ IDU and 0.25% BVDU were effective in our ocular model of HSV-1 keratitis, whereas thymine arabinoside was not.

Author Affiliations
From the Department of Cornea Research, Eye Research Institute of Retina Foundation (Drs Hettinger, Pavan-Langston, and Park), and the Department of Ophthalmology, Harvard Medical School (Drs Hettinger, Pavan-Langston, Park, and Albert), Boston; the Rega Institute for Medical Research, University of Leuven, Belgium (Dr De Clercq); and the Department of Pharmacology, Yale University School of Medicine, New Haven, Conn (Dr Lin). Dr Hettinger is now with the University of Kansas, Kansas City.

Footnotes
Accepted for publication Oct 25, 1980.

Read in part before the Association of Research in Vision and Ophthalmology, Orlando, Fla, May 7, 1980.

Reprint requests to the Department of Ophthalmology, the University of Kansas, 39th and Rainbow Boulevard, Kansas City, KN 66103 (Dr Hettinger).

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