This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (48)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Analysis of a Five-Year Observation Period After Corneal Ulceration

Kirk R. Wilhelmus, MD; Douglas J. Coster, FRACS; Hugh C. Donovan, BSc; Michael G. Falcon, FRCS; Barrie R. Jones, FRCS

Arch Ophthalmol. 1981;99(9):1578-1582.

Abstract
• Clinical features of 152 patients with herpetic keratitis after a five-year observation period were analyzed. When compared with dendritic ulceration, geographic ulcers that had been symptomatically present for a longer time were more likely to have been treated with a topical steroid and took longer to heal. After treatment of the corneal ulceration, 40% of the patients experienced a recurrent herpetic ulcer, 25% experienced disciform or irregular stromal keratouveitis, 5% experienced ocular hypertension, and 6% had a decrease in visual acuity caused by corneal scarring. Recurrent ulcerative herpetic keratitis occurred more frequently in men and in patients who entered the study with a history of previous herpetic ulceration.

Author Affiliations
From the Departments of Clinical Ophthalmology (Drs Wilhelmus, Coster, and Falcon) and Preventive Ophthalmology (Dr Jones), Moorfields Eye Hospital; and the Computer Section (Mr Donovan), Institute of Ophthalmology, London. Dr Coster is now with The Flinders University of South Australia, Adelaide.

Footnotes
Accepted for publication Dec 29, 1980.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prevention of Herpes Simplex Virus Eye Disease: A Cost-effectiveness Analysis
Lairson et al.
Arch Ophthalmol 2003;121:108-112.
ABSTRACT | FULL TEXT  

The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
Halberstadt et al.
Br J Ophthalmol 2002;86:646-652.
ABSTRACT | FULL TEXT  

Acyclovir for Recurrent Herpes Simplex Virus Ocular Disease
Jabs
NEJM 1998;339:340-341.
FULL TEXT  

A Controlled Trial of Oral Acyclovir for the Prevention of Stromal Keratitis or Iritis in Patients With Herpes Simplex Virus Epithelial Keratitis: The Epithelial Keratitis Trial
The Herpetic Eye Disease Study Group
Arch Ophthalmol 1997;115:703-712.
ABSTRACT  

Recurrent Herpes Simplex Keratitis With Concurrent Epithelial and Stromal Involvement: Immunohistochemical and Ultrastructural Observations
Holbach et al.
Arch Ophthalmol 1991;109:692-695.
ABSTRACT  

Epidemiology of Ocular Herpes Simplex: Incidence in Rochester, Minn, 1950 Through 1982
Liesegang et al.
Arch Ophthalmol 1989;107:1155-1159.
ABSTRACT  

Epidemiology of Ocular Herpes Simplex: Natural History in Rochester, Minn, 1950 Through 1982
Liesegang
Arch Ophthalmol 1989;107:1160-1165.
ABSTRACT