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  Vol. 99 No. 8, August 1981 TABLE OF CONTENTS
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Orbital Metastasis From Prostatic Carcinoma

Identification by an Immunoperoxidase Technique

Charles F. Winkler, MD; Glen K. Goodman, MD; Richard A. Eiferman, MD; Lung T. Yam, MD

Arch Ophthalmol. 1981;99(8):1406-1408.


Abstract



• A patient was seen initially with an orbital tumor causing blindness of the left eye. Although disseminated prostatic carcinoma was found, the origin of the orbital tumor was not established until prostate antigen was demonstrated in biopsy specimens by an immunoperoxidase technique. Orbital metastasis from prostatic carcinoma has been reported in 16 cases. Confirmation of the diagnosis may be difficult and, in the past, has largely been indirect as judged by clinical trial. The immunoperoxidase technique for detecting prostate antigen in tissue sections is both sensitive and specific. Application of this technique resulted in the diagnosis of this unusual manifestation of metastatic prostate cancer. The possibility of additional clinical applications of this immunohistochemical technique within the field of ophthalmology is raised.



Author Affiliations



From the Sections of Hematology (Drs Winkler and Yam) and Ophthalmology (Drs Goodman and Eiferman), Veterans Administration Medical Center, Louisville; and Trover Clinic (Dr Winkler), Madisonville, Ky.


Footnotes



Accepted for publication Oct 23, 1980.

Reprint requests to the Veterans Administration Medical Center, Louisville, KY 40202 (Dr Winkler).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Orbital Metastases From Prostate Carcinoma
Boldt and Nerad
Arch Ophthalmol 1988;106:1403-1408.
ABSTRACT  

Orbital Metastasis From Prostatic Carcinoma: Identification by Immunocytology
Reifler et al.
Arch Ophthalmol 1984;102:292-295.
ABSTRACT  





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