Orbital metastasis from prostatic carcinoma. Identification by an immunoperoxidase technique
C. F. Winkler, G. K. Goodman, R. A. Eiferman and L. T. Yam
A patient was seen initially with an orbital tumor causing blindness of the
left eye. Although disseminated prostatic carcinoma was found, the origin
of the orbital tumor was not established until prostate antigen was
demonstrated in biopsy specimens by an immunoperoxidase technique. Orbital
metastasis from prostatic carcinoma has been reported in 16 cases.
Confirmation of the diagnosis may be difficult and, in the past, has
largely been indirect as judged by clinical trial. The immunoperoxidase
technique for detecting prostate antigen in tissue sections is both
sensitive and specific. Application of this technique resulted in the
diagnosis of this technique resulted in the diagnosis of this unusual
manifestation of metastatic prostate cancer. The possibility of additional
clinical applications of this immunohistochemical technique within the
field of ophthalmology is raised.