S-antigen uveitis in primates. A new model for human disease
R. B. Nussenblatt, T. Kuwabara, F. M. de Monasterio and W. B. Wacker
Uveitis was induced rhesus monkeys immunized with purified retinal
S-antigen. Focal retinal and subretinal infiltration, in addition to
periphlebitic changes, were observed histologically. Immunized monkeys had
similar cell-mediated in vitro immune responses to the S-antigen as do
humans with posterior uveitis. Circulating immune complexes at the time of
disease could not be detected. This primate model supports the notion that
the S-antigen may play a role in human uveitis.
