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A New Model for Human Disease

Robert B. Nussenblatt, MD; Toichiro Kuwabara, MD; Francisco M. de Monasterio, MD, DSc; Waldon B. Wacker, PhD

Arch Ophthalmol. 1981;99(6):1090-1092.

Abstract
• Uveitis was induced in rhesus monkeys immunized with purified retinal Santigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cellmediated in vitro immune responses to the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time of disease could not be detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.

Author Affiliations
From the Clinical Branch (Drs Nussenblatt and de Monasterio) and Laboratory for Vision Research (Dr Kuwabara), National Eye Institute, Bethesda, Md; and Department of Ophthalmology, University of Louisville (Dr Wacker).

Footnotes
Accepted for publication Sept 29, 1980.

Reprint requests to National Eye Institute, National Institutes of Health, Bldg 10, Room 10D-09, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Nussenblatt).

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