Ocular toxicity of topical antifungal agents
C. S. Foster, J. H. Lass, K. Moran-Wallace and R. Giovanoni
We studied, in a rabbit, the ocular toxicity of topical 1% solutions or
suspensions of amphotericin B, flucytosine, miconazole nitrate, and
ketoconazole. Flucytosine, miconazole, and ketoconazole did not retard the
closure of 8.5-mm corneal epithelial defects; amphotericin B greatly
retarded the closure of such defects. Amphotericin B produced dramatic
pathologic changes in this model; these changes worsened with each day of
therapy. Ketoconazole produced modest biomicroscopically and histologically
detectable pathologic changes in the regenerating corneal epithelium;
flucytosine and miconazole did not produce such changes.
