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Lawrence W. Hirst, MD; Kenneth R. Kenyon, MD; Jerry A. Fogle, MD; Laila Hanninen; Walter J. Stark, MD

Arch Ophthalmol. 1981;99(6):1066-1073.

Abstract
• This animal study of corneal surface injury using acid, alkali n-heptanol, iodine, keratectomy, or scraping, despite morphologic differences from the human, simulated the human response to these forms of trauma. The rabbit and monkey thus remain useful models for the study of the effects of chemical and physical injury on the corneal surface. Although abnormalities in the basement membrane complex seem to play an important role in corneal epithelial adhesion problems, the presence of a poor substratum on which adhesion complexes must in turn rely for their stromal attachment is also an important factor.

Author Affiliations
From the Cornea Service, the Wilmer Institute, The Johns Hopkins Hospital, Baltimore (Drs Hirst and Stark); and the Department of Cornea Research and Morphology Unit, Eye Research Institute of Retina Foundation, and the Department of Ophthalmology, Harvard Medical School, Boston (Drs Kenyon and Fogle and Ms Hanninen).

Footnotes
Accepted for publication June 24, 1980.

Presented at the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 1, 1979.

Reprint requests to the Wilmer Institute, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Hirst).

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