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An Experimental Study

Verinder S. Nirankari, MD; Shambu D. Varma, PhD; Vinod Lakhanpal, MD; Richard D. Richards, MD

Arch Ophthalmol. 1981;99(5):886-887.

Abstract
• To test the hypothesis that superoxide radicals are involved in tissue destruction after alkali burns, superoxide dismutase, ascorbic acid, and glutathione were used as superoxide radical scavenging agents. Daily subconjunctival injections were given in rabbit eyes after alkali burns. Both superoxide dismutase and ascorbic acid were effective in preventing corneal perforations. Glutathione did not show any beneficial effect. These experiments suggest that superoxide radical scavenging agents may be useful in the treatment of ocular alkali burns.

Author Affiliations
From the Department of Ophthalmology, University of Maryland School of Medicine, Baltimore.

Footnotes
Accepted for publication Aug 8, 1980.

Reprint requests to Department of Ophthalmology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (Dr Nirankari).

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