Human Massive Periretinal Proliferation: In Vitro Characteristics of Cellular Components

doi:10.1001/archopht.1981.03930010873017

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Vol. 99 No. 5, May 1981

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Human Massive Periretinal Proliferation

In Vitro Characteristics of Cellular Components

David A. Newsome, MD; Merlyn M. Rodrigues, MD; Robert Machemer, MD

Arch Ophthalmol. 1981;99(5):873-880.

Abstract

• The sources of cellular constituents of fibrous and cellophanemembranes formed in massive periretinal proliferation have beenunclear. We successfully obtained cellular outgrowths from abnormalvitreous specimens collected at surgery for massive periretinalproliferation in 13 patients, using standard culture techniques.By phase-contrast and ultrastructural morphological criteria,we identified four major cellular constituents: (1) macrophagespresent in all specimens; (2) pigmented epithelioid cells, presentin a majority of specimens; (3) glial-like cells, present ina majority of specimens; and (4) fibroblastic cells, presentin all specimens but much more prominent in grossly fibroustissues. Our findings confirm published reports of pigmentedepithelioid cells and glial-like cells in fixed surgical specimensand advance our understanding of the heterogeneity of pathologiccells active in producing this serious complication of retinalreattachment surgery.

Author Affiliations

From the Sections on Retinal and Connective Tissue Diseases (Dr Newsome) and Clinical Eye Pathology (Dr Rodrigues), Clinical Branch, National Eye Institute, Bethesda, Md; and the Duke University Eye Center, Durham, NC (Dr Machemer).

Footnotes

Accepted for publication June 20, 1980.

Reprint requests to Bldg 10, Room 10 D-17, National Institutesof Health, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Newsome).

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