Clinical types of corneal transplant rejection. Their manifestations, frequency, preoperative correlates, and treatment
O. C. Alldredge and J. H. Krachmer
We report a retrospective series of 156 penetrating keratoplasties that
were performed in 144 patients during a two-year period, with a minimum of
one-year follow-up. Three different types of rejection were
identified--endothelial rejection, epithelial rejection, and subepithelial
infiltrates (SEIs). We also report the clinical signs, frequency,
preoperative correlates, significance, and treatment of each type of
rejection. The overall frequency of any kind of rejection was 29%.
Endothelial rejection was seen in 21% of the grafts, epithelial rejection
was seen in 10% of the grafts, and SEIs was seen in 15% of the grafts. The
frequency of endothelial rejection increased with preoperative corneal
vascularization. All three types of rejection decreased in frequency with
the increasing age of the recipient. Endothelial rejection was more
successfully treated in the cases that had no preoperative stromal
vascularization.
The Corneal Epithelial Stem Cell Puzzle: What Future Discoveries Lie on the Horizon?
Kinoshita
Arch Ophthalmol 2008;126:725-726.
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Adipose-Derived Stem Cells Are a Source for Cell Therapy of the Corneal Stroma
Arnalich-Montiel et al.
Stem Cells 2008;26:570-579.
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Corneal Innervation and Cellular Changes after Corneal Transplantation: An In Vivo Confocal Microscopy Study
Niederer et al.
IOVS 2007;48:621-626.
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Factors Influencing the Decline in Endothelial Cell Density after Corneal Allograft Rejection
Claerhout et al.
IOVS 2003;44:4747-4752.
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Corneal Epithelial Rejection in the Rat
Figueiredo et al.
IOVS 2002;43:729-736.
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Missense mutations in COL8A2, the gene encoding the {alpha}2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy
Biswas et al.
Hum Mol Genet 2001;10:2415-2423.
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Dynamics of Donor Cell Persistence and Recipient Cell Replacement in Orthotopic Corneal Allografts in Mice
Hori and Streilein
IOVS 2001;42:1820-1828.
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Role of Recipient Epithelium in Promoting Survival of Orthotopic Corneal Allografts in Mice
Hori and Streilein
IOVS 2001;42:720-726.
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Fine Needle Diathermy Occlusion of Corneal Vessels
Pillai et al.
IOVS 2000;41:2148-2153.
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Randomised controlled trial of corticosteroid regimens in endothelial corneal allograft rejection
Hudde et al.
Br. J. Ophthalmol. 1999;83:1348-1352.
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A murine model of interlamellar corneal transplantation
Lau et al.
Br. J. Ophthalmol. 1998;82:294-299.
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