H2-receptors in the human ocular surface
M. B. Abelson and I. J. Udell
Ten normal human volunteers participated in a two-part study of H2-receptor
activity in the ocular surface. Dimethylaminopropylisothiourea (trivial
name, dimaprit dihydrochloride), a highly selective H2-receptor agonist,
produced vasodilation without itch. Pretreatment with the H2-receptor
antagonist, cimetidine, significantly blocked the vasodilatory effect of
dimethylaminopropylisothiourea, whereas pretreatment with the H1-receptor
antagonist, antazoline phosphate, did not. We conclude that H2-receptors
are present in the human ocular surface.
