Endogenous Candida albicans endophthalmitis in the rabbit. Chemotherapy for systemic effect
D. B. Jones, M. T. Green, M. S. Osato, P. H. Broberg and L. O. Gentry
Progressive endogenous Candida albicans endophthalmitis was established in
rabbits by intravenous (IV) injection of blastospores (2.0 to 5.0 x 10/kg).
Severity of infection was directly related to the strain and inoculum size.
Intravenous amphotericin B (1.0 mg/kg/day), IV amphotericin B methyl ester
ascorbate (5.0 mg/kg/day), and oral ketoconazole (80 mg/kg/day) effectively
prevented or reduced the severity of infection when therapy was initiated
24 hours following inoculation of blastospores and continued for five to
seven days. Intravenous miconazole (30 mg/kg/day) was ineffective in this
model. Intravenous amphotericin B(1.0 to 2.0 mg/kg on alternate days), IV
amphotericin B methyl ester ascorbate (5.0 mg/kg/day), and oral
ketoconazole (80 mg/kg/day reduced the severity of C albicans
endophthalmitis when therapy was initiated seven days following injection
of blastospores and continued for 28 days. Oral flucytosine (75 and 150
mg/kg/day in four doses) produced uniformly fatal hepatic necrosis in
uninfected rabbits.
