This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Chemotherapy for Systemic Effect

Dan B. Jones, MD; Mary T. Green, PhD; Michael S. Osato, PhD; Peter H. Broberg, MD; Layne O. Gentry, MD

Arch Ophthalmol. 1981;99(12):2182-2187.

Abstract
• Progressive endogenous Candida albicans endophthalmitis was established in rabbits by intravenous (IV) injection of blastospores (2.0 to 5.0 x 10⁵/kg). Severity of infection was directly related to the strain and inoculum size. Intravenous amphotericin B (1.0 mg/kg/day), IV amphotericin B methyl ester ascorbate (5.0 mg/kg/day), and oral ketoconazole (80 mg/kg/day) effectively prevented or reduced the severity of infection when therapy was initiated 24 hours following inoculation of blastospores and continued for five to seven days. Intravenous miconazole (30 mg/kg/day) was ineffective in this model. Intravenous amphotericin B (1.0 to 2.0 mg/kg on alternate days), IV amphotericin B methyl ester ascorbate (5.0 mg/kg/day), and oral ketoconazole (80 mg/kg/day) reduced the severity of C albicans endophthalmitis when therapy was initiated seven days following injection of blastospores and continued for 28 days. Oral flucytosine (75 and 150 mg/ kg/day in four doses) produced uniformly fatal hepatic necrosis in uninfected rabbits.

Author Affiliations
From the Departments of Ophthalmology (Drs Jones, Green, Osato, and Broberg) and Medicine (Dr Gentry), Baylor College of Medicine, Houston.

Footnotes
Accepted for publication Feb 3, 1981.

Reprint requests to Cullen Eye Institute, Texas Medical Center, Houston, TX 77030 (Dr Jones).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Efficacies of High-Dose Fluconazole plus Amphotericin B and High-Dose Fluconazole plus 5-Fluorocytosine versus Amphotericin B, Fluconazole, and 5-Fluorocytosine Monotherapies in Treatment of Experimental Endocarditis, Endophthalmitis, and Pyelonephritis Due to Candida albicans
Louie et al.
Antimicrob. Agents Chemother. 1999;43:2831-2840.
ABSTRACT | FULL TEXT