 |
|
Actin Filaments in Diabetic Fibrovascular Preretinal Membrane
Ingolf H. L. Wallow, MD;
Marion L. Greaser, PhD;
Thomas S. Stevens, MD
Arch Ophthalmol. 1981;99(12):2175-2181.
Abstract
• A vitrectomy specimen from a diabetic patient was studied by light and electron microscopy using myosin subfragment 1 to decorate and identify actin filaments. The patient had proliferative diabetic retinopathy, a shrinking fibrovascular preretinal membrane associated with retraction of the thickened posterior hyaloid, and a localized traction retinal detachment. The fibrovascular tissue comprised normal mature collagen, few cells, and occasional blood vessels. The cells contained numerous thick bundles of the contractile protein, actin. We suggest that actin may have been involved in the contraction phenomena observed clinically and that membrane contraction might be blocked by pharmacologic treatment.
Author Affiliations
From the Department of Ophthalmology (Drs Wallow and Stevens) and the Muscle Biology Laboratory (Dr Greaser), University of Wisconsin, Madison.
Footnotes
Accepted for publication Feb 3, 1981.
Reprint requests to Department of Ophthalmology, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI 53792 (Dr Wallow).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Diabetic Preretinal Membranes: An Immunohistochemical Study
Jerdan et al.
Arch Ophthalmol 1986;104:286-290.
ABSTRACT
In Situ Actin Distribution in Excised Retrolental Membranes in Retinopathy of Prematurity
Soong et al.
Arch Ophthalmol 1985;103:1553-1556.
ABSTRACT
Actin Filaments in Contracting Preretinal Membranes
Wallow et al.
Arch Ophthalmol 1984;102:1370-1375.
ABSTRACT
|
