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Ronald L. Radius, MD; Margaret Gonzales

Arch Ophthalmol. 1981;99(12):2159-2162.

Abstract
• Light microscopy of specimens of human eyes cut in cross section at the level of the lamina cribrosa showed variation in structural anatomy, as demonstrated previously in certain primate eyes. Connective tissue and glial cell structural elements were greater in nasal-temporal as compared with inferior and superior quadrants of the disc. This regional variation suggests a hypothesis for the specificity of early patterns of optic nerve dysfunction characteristic of glaucomatous optic neuropathy. In glaucomatous eyes, nerve head regions with relatively less structural tissue elements may yield early to detrimental effects of persistent pressure elevation.

Author Affiliations
From the Eye Institute, Medical College of Wisconsin, Milwaukee.

Footnotes
Accepted for publication March 5, 1981.

Reprint requests to Eye Institute, Medical College of Wisconsin, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Radius).

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