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An Electron Microscopic Study of Rabbit Cornea

Tatsuo Yamaguchi, MD; Frank M. Polack, MD; John Valenti; Herbert E. Kaufman, MD

Arch Ophthalmol. 1981;99(12):2151-2158.

Abstract
• Anterior radial keratotomy was performed on the left eyes of 21 rabbits. Specimens were taken for electron microscopic examination at intervals during a three-month period. The corneas were acutely inflamed for three days after surgery. Some endothelial cells beneath the incisions were damaged, and distended intercellular spaces were seen. Deeper incisions seemed to produce more severe damage. With increasing time after surgery, some of the damaged endothelial cells seemed to be recovering, while others in the areas between the incisions and in the center of the cornea were degenerating. Three months after surgery, the endothelium had recovered, but some of the peripheral intercellular spaces still were distended. These findings may be the result of continuous blinking in combination with the structural weakness of the cornea, rather than a result of chronic postsurgical inflammation.

Author Affiliations
From the Lions Eye Research Laboratories, Louisiana State University (LSU) Eye Center, LSU Medical Center School of Medicine, New Orleans (Drs Yamaguchi and Kaufman); and the Department of Ophthalmology, University of Florida College of Medicine, Gainesville (Dr Polack and Mr Valenti).

Footnotes
Accepted for publication Feb 13, 1981.

Reprint requests to the LSU Eye Center, 136 S Roman St, New Orleans, LA 70112 (Dr Yamaguchi).

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